Professor Grimson did an MSc in Computer Science at the University of Toronto before returning to Scotland, the land of her birth, to do a PhD at the University of Edinburgh.
Jane returned to Trinity College Dublin in 1980 to take up a post as lecturer in Computer Science. She was first female Dean of Engineering, of Research and Vice Provost. In addition to her lecturing duties, Jane is an active researcher principally in the field of health informatics, where her work on electronic health records and system integration has had a significant impact on the development of international standards. She was co-founder of the inter-disciplinary Centre for Health Informatics at Trinity College and also chaired the Trinity International Development Initiative. She was appointed Pro-Chancellor of the University of Dublin in 2016.
Jane is an active member of a number of professional organisations including the Engineers Ireland (formerly the Institution of Engineers of Ireland, IEI), the Irish Computer Society (ICS) and the Health Informatics Society of Ireland. She was President of the Institution of Engineers of Ireland from 1999-2000, of the Irish Academy of Engineering in 2004, of the Irish Computer Society from 2000 - 2004 and of the Health Informatics Society of Ireland from 1999 - 2007. She is currently a Vice-President of the Royal Irish Academy.
She is committed to the integration of software engineering into the mainstream of the engineering profession and has worked with both the Engineers Ireland and the Irish Computer Society to promote this approach within Ireland. She also has a particular interest in promoting engineering generally as a career among young women and has chaired a committee in the Department of Education and Science aimed at increasing the participation of girls in careers in Science, Engineering and Technology. She has also served as a member of the Board of Science Foundation Ireland, as member and chair of the Irish Research Council for Science, Engineering and Technology, as a member of the European Research Advisory Board and the Executive of the European Science Foundation. She is currently a member of the Health Research Board. She is a strong advocate of open access publication and open science generally.
In 2007, Professor Grimson was awarded the O'Moore Medal for her contribution to the development of Healthcare Informatics in Ireland. In 2004 she was elected an international fellow of the Royal Academy of Engineering and as a member of the Royal Irish Academy in 2009.
In 2007 she began a period of partial secondment as Director of Health Information in the newly established Health Information and Quality Authority (HIQA), the health and social care regulator in Ireland. She brought to HIQA many years of experience in the field of health informatics to lead the development of health information and health informatics standards nationally. Prior to her retirement in 2014, she served a period as Acting Chief Executive of HIQA.